Amikacin Sulfate Salt( —— )

Catalog No. M12062 CAS No. 149022-22-0

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Product Name

Amikacin Sulfate Salt
Note

Research use only, not for human use.
Brief Description

A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
Description

A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
In Vitro

Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides, Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi).Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50 value of 453 μM.
In Vivo

Amikacin (320?mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo. Animal Model:Male Fischer 344 rats (40-50-day-old) Dosage:320?mg/kg Administration: Subcutaneous injection; daily; for 10 days Result:Induced hearing loss in rats.
Synonyms

——
Pathway

Microbiology/Virology
Target

ribosome
Recptor

30S ribosome
Research Area

——
Indication

——

CAS Number

149022-22-0
Formula Weight

683.68
Molecular Formula

C22H45N5O17S
Purity

>98% (HPLC)
Solubility

Soluble in Water
SMILES

OS(O)(=O)=O.NCCC(O)C(=O)NC1CC(N)C(OC2OC(CN)C(O)C(O)C2O)C(O)C1OC1OC(CO)C(O)C(N)C1O
Chemical Name

——

1.Tolmasky ME. Front Biosci. 2000 Jan 1;5:D20-9.

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